The steroid hormone vitamin D exerts extensive control over gene expression, modulating over 2,000 genes in the human genome. In this regard it plays an integral role in the regulation of the antioxidant status (redox balance) of the cell. There is increasing evidence that a deficiency in vitamin D contributes to many human diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, hypertension, and cardiovascular disease. Many of the major diseases in humans linked to vitamin D deficiency are associated with dysregulation in both cellular redox status and calcium signalling.
The ability of the vitamin to maintain healthy cells involves its role in modulating those signalling systems involving redox balance and calcium metabolism.11 There is evidence that vitamin D, working with klotho, a hormone involved with regulation of the aging process, maintains molecular signalling systems that promote growth, development, and the redox status of tissues critical for normal physiology.12 Vitamin D is known to directly regulate Nrf2, the master switch controlling the manufacture of endogenous antioxidants, and the processes of detoxification in the liver.12;13
NutriSearch Corporation is a Canadian company specializing in nutrition and health research, focussed primarily on multiple vitamin and mineral supplementation.
Our main product is the NutriSearch Comparative Guide to Nutritional Supplements™, which examines current research on the health benefits of supplementation for prevention of degenerative disease. The guide also includes comparisons of broad-spectrum supplements available in various markets around the world, is available in various regions. The guide for the Americas includes product comparisons from Canada, Colombia, México, and the United States. We also publish a guide for Australia and New Zealand.
NutriSearch is also available as a consultant to nutritional supplement manufacturers wanting to improve their supplements.