LifeSpan Essentials

Reference List

  1. Pounis G, Di CA, Bonaccio M et al. Flavonoid and lignan intake in a Mediterranean population: proposal for a holistic approach in polyphenol dietary analysis, the Moli-sani Study. Eur J Clin Nutr 2016;70:338-345.
  2. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000;130:2073S-2085S.
  3. Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 1998;68:1081-1087.
  4. Prior RL, Cao G. Antioxidant Phytochemicals in Fruits and Vegetables: Diet and Health Implications. HortScience 2000;35(4):588-592.
  5. Blanco-Ayala T, Anderica-Romero AC, Pedraza-Chaverri J. New insights into antioxidant strategies against paraquat toxicity. Free Radic Res 2014;48:623-640.
  6. Phillipson OT. Management of the aging risk factor for Parkinson's disease. Neurobiol Aging 2014;35:847-857.
  7. Deng C, Sun Z, Tong G et al. alpha-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway. PLoS One 2013;8:e58371.
  8. Lin YC, Lai YS, Chou TC. The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. Evid Based Complement Alternat Med 2013;2013:590363.
  9. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 2009;1790:1149-1160.
  10. Wagner AE, Ernst IM, Birringer M, Sancak O, Barella L, Rimbach G. A combination of lipoic acid plus coenzyme Q10 induces PGC1alpha, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. Oxid Med Cell Longev 2012;2012:835970.
  11. Berridge MJ. Vitamin D: a custodian of cell signalling stability in health and disease. Biochem Soc Trans 2015;43:349-358.
  12. Haussler MR, Whitfield GK, Haussler CA et al. 1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age. Vitam Horm 2016;100:165-230.
  13. Jimenez-Osorio AS, Gonzalez-Reyes S, Pedraza-Chaverri J. Natural Nrf2 activators in diabetes. Clin Chim Acta 2015;448:182-192.
  14. Chen JX, Li G, Wang H et al. Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice. Cancer Lett 2016;371:71-78.
  15. Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001;74:714-722.
  16. Elisia I, Kitts DD. Modulation of NF-kappaB and Nrf2 control of inflammatory responses in FHs 74 Int cell line is tocopherol isoform-specific. Am J Physiol Gastrointest Liver Physiol 2013;305:G940-G949.
  17. Peh HY, Ho WE, Cheng C et al. Vitamin E Isoform gamma-Tocotrienol Downregulates House Dust Mite-Induced Asthma. J Immunol 2015;195:437-444.
  18. Das GS, So JY, Wall B et al. Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats. Mol Carcinog 2015;54:916-925.
  19. Ogawa Y, Saito Y, Nishio K, Yoshida Y, Ashida H, Niki E. Gamma-tocopheryl quinone, not alpha-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4. Free Radic Res 2008;42:674-687.
  20. Smolarek AK, So JY, Thomas PE et al. Dietary tocopherols inhibit cell proliferation, regulate expression of ERalpha, PPARgamma, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog 2013;52:514-525.
  21. Kannappan R, Gupta SC, Kim JH, Aggarwal BB. Tocotrienols fight cancer by targeting multiple cell signaling pathways. Genes Nutr 2012;7:43-52.
  22. Hsieh TC, Elangovan S, Wu JM. Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes. Anticancer Res 2010;30:4169-4176.
  23. Foresti R, Bucolo C, Platania CM, Drago F, Dubois-Rande JL, Motterlini R. Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions. Pharmacol Res 2015;99:296-307.
  24. Cai Z, Lou Q, Wang F et al. N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway. Int J Clin Exp Pathol 2015;8:8655-8662.
  25. Zhang L, Zhu Z, Liu J, Zhu Z, Hu Z. Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway. J Recept Signal Transduct Res 2014;34:396-400.
  26. Kim S, Lee HG, Park SA et al. Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. PLoS One 2014;9:e85984.
  27. Ji L, Liu R, Zhang XD et al. N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression. Inhal Toxicol 2010;22:535-542.
  28.   Chen G, Shi J, Hu Z, Hang C. Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm 2008;2008:716458.
  29. Kim H, Seo JY, Roh KH, Lim JW, Kim KH. Suppression of NF-kappaB activation and cytokine production by N-acetylcysteine in pancreatic acinar cells. Free Radic Biol Med 2000;29:674-683.
  30. McCarty MF, DiNicolantonio JJ. An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly. Age (Dordr ) 2015;37:96.
  31. Dinkova-Kostova AT, Abramov AY. The emerging role of Nrf2 in mitochondrial function. Free Radic Biol Med 2015;88:179-188.
  32. Denzer I, Munch G, Friedland K. Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds. Pharmacol Res 2016;103:80-94.
  33. Kerns ML, Hakim JM, Lu RG et al. Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes. J Clin Invest 2016.
  34. Furuya AK, Sharifi HJ, Jellinger RM, Cristofano P, Shi B, de Noronha CM. Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2. PLoS Pathog 2016;12:e1005581.
  35. Doss JF, Jonassaint JC, Garrett ME, Ashley-Koch AE, Telen MJ, Chi JT. Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease. PLoS One 2016;11:e0152895.
  36. Yu JS, Chen WC, Tseng CK et al. Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway. PLoS One 2016;11:e0152236.
  37. Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol 2016;43:146-153.
  38. An YW, Jhang KA, Woo SY, Kang JL, Chong YH. Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages. Neurobiol Aging 2016;38:1-10.
  39. Feng S, Xu Z, Wang F et al. Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway. Mol Neurobiol 2016.
  40. Townsend BE, Johnson RW. Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior. Nutr Neurosci 2015.
  41. Yin XP, Chen ZY, Zhou J, Wu D, Bao B. Mechanisms underlying the perifocal neuroprotective effect of the Nrf2-ARE signaling pathway after intracranial hemorrhage. Drug Des Devel Ther 2015;9:5973-5986.
  42. Houghton CA, Fassett RG, Coombes JS. Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? Oxid Med Cell Longev 2016;2016:7857186.
  43. Wang W, He Y, Yu G et al. Sulforaphane Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity. PLoS One 2015;10:e0138771.
  44. Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol 2016;43:146-153.
  45. Wu H, Kong L, Cheng Y et al. Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2. Free Radic Biol Med 2015;89:431-442.
  46. Hecht SS, Chung FL, Richie JP, Jr. et al. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol Biomarkers Prev 1995;4:877-884.
  47. Higdon J. Isothiocyanates. Linus Pauling Institute [serial online] 2016; Accessed May 23, 2016.

Contact Us

NutriSearch Corporation
204-290 Hwy 33 E
Kelowna, BC V1X 2A3
Canada
Phone: (250) 765-5005
Email: cs@nutrisearch.ca

About Us

NutriSearch Corporation is a Canadian company specializing in nutrition and health research, focussed primarily on multiple vitamin and mineral supplementation.

Our main product is the NutriSearch Comparative Guide to Nutritional Supplements, which examines current research on the health benefits of supplementation for prevention of degenerative disease. The guide also includes comparisons of broad-spectrum supplements available in various markets around the world, is available in various regions. The guide for the Americas includes product comparisons from Canada, Colombia, México, and the United States. We also publish a guide for Australia and New Zealand.

NutriSearch is also available as a consultant to nutritional supplement manufacturers wanting to improve their supplements.