Resveratrol has been of great scientific interest due to the large number of studies suggesting its preventive and protective effects against cancer and heart disease.4 Found in grape skins, red wine, and a large variety of berry fruits, resveratrol mimics the effects of calorie restriction by favourably modulating gene expression to increase cell autophagy.5;6 Research confirms that the polyphenol directly inhibits the mTOR-ULK1 signalling pathway that regulates cellular degradation processes.7 It also tempers deadly inflammation by activating a powerful family of information regulator proteins, called sirtuins, that inhibit activation of the inflammation regulator NF-kB.8 Through its ability to directly influence SIRT1, known as the longevity gene, resveratrol favourably influences other genes that positively affect lifespan.
Doses of 20-50 mg/day of resveratrol lead to concentrations in the blood sufficient to induce cellular signalling. As well, animal-model studies conducted by Life Extension Foundation researchers demonstrated favourable anti-aging gene expression in mice that received the equivalent of 20 mg/day of resveratrol.9 A review of clinical evidence on the efficacy of resveratrol calls for caution when extrapolating animal-model studies to humans and suggests a low-dose figure for daily intake of 15-20 mg, which is about equivalent to the resveratrol intake from the consumption of 1 litre of organically grown red wine (the author, however, is not suggesting this be your principal daily source of resveratrol).10
While acknowledging the data is sparse, NutriSearch has incorporated a daily intake of 20 mg of resveratrol as an optimal intake for healthy living.
NutriSearch Corporation is a Canadian company specializing in nutrition and health research, focussed primarily on multiple vitamin and mineral supplementation.
Our main product is the NutriSearch Comparative Guide to Nutritional Supplements™, which examines current research on the health benefits of supplementation for prevention of degenerative disease. The guide also includes comparisons of broad-spectrum supplements available in various markets around the world, is available in various regions. The guide for the Americas includes product comparisons from Canada, Colombia, México, and the United States. We also publish a guide for Australia and New Zealand.
NutriSearch is also available as a consultant to nutritional supplement manufacturers wanting to improve their supplements.